T cell antigen receptor gene rearrangement in refractory anemia with excess of blasts(RAEB).
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چکیده
منابع مشابه
Diversity of T-cell receptor Gene Rearrangements in South Indian Patients with Common Acute Lymphoblastic Leukemia
Background: Precursor B-Acute Lymphoblastic Leukemia (precursor B-ALL) oc-curs due to the uncontrolled proliferation of B-lymphoid precursors arrested at a par-ticular stage of B-cell development. Precursor-B-ALL is classified mainly into pro-B-ALL, common-ALL and pre-B-ALL. The Common Acute Lymphoblastic Antigen CD10 is the marker for common-ALL. Objective: This study was aimed to examine the ...
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V(D)J recombination assembles antigen-specific immunoglobulin and T-cell receptor variable region genes from germline V, D, and J segments during lymphocyte development. Regulation of this site-specific DNA rearrangement process occurs with respect to the cell type and stage of differentiation, order of locus recombination, and allele usage. Many of these controls are mediated via the modulatio...
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T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor S-chain gene in the absence of rearrangement of the y-chain gene. To our knowledge, this has not been previously reported. This finding was unexpected in light of prevailing concepts of T cell ontogeny. Potential explanations for it are discussed. 6 1990 Academic PESS, IK.
متن کاملStochastic Modeling of T cell receptor g gene rearrangement
The mechanisms controlling the recombination process of the g genes that encode the g chain of the antigen receptor of the gd T lymphocytes are unclear. Based on experimental data on the recombination status of the two major TCR g genes expressed in V g4þ and V g1þ thymocytes, we tested the plausibility of three possible rearrangement mechanisms: (1) a time window mechanism according to which t...
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ژورنال
عنوان ژورنال: Nihon Naika Gakkai Zasshi
سال: 1988
ISSN: 0021-5384,1883-2083
DOI: 10.2169/naika.77.1246